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Changing appetites: the adaptive advantages of fuel choice.
- Source :
-
Trends in cell biology [Trends Cell Biol] 2014 Feb; Vol. 24 (2), pp. 118-27. Date of Electronic Publication: 2013 Sep 07. - Publication Year :
- 2014
-
Abstract
- Cells are capable of metabolizing a variety of carbon substrates, including glucose, fatty acids, ketone bodies, and amino acids. Cellular fuel choice not only fulfills specific biosynthetic needs, but also enables programmatic adaptations to stress conditions beyond compensating for changes in nutrient availability. Emerging evidence indicates that specific switches from utilization of one substrate to another can have protective or permissive roles in disease pathogenesis. Understanding the molecular determinants of cellular fuel preference may provide insights into the homeostatic control of stress responses, and unveil therapeutic targets. Here, we highlight overarching themes encompassing cellular fuel choice; its link to cell fate and function; its advantages in stress protection; and its contribution to metabolic dependencies and maladaptations in pathological conditions.<br /> (Copyright © 2013 Elsevier Ltd. All rights reserved.)
- Subjects :
- Cell Differentiation
Cells pathology
Humans
Cells metabolism
Energy Metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1879-3088
- Volume :
- 24
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Trends in cell biology
- Publication Type :
- Academic Journal
- Accession number :
- 24018218
- Full Text :
- https://doi.org/10.1016/j.tcb.2013.07.010