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Protein S levels and the risk of venous thrombosis: results from the MEGA case-control study.
- Source :
-
Blood [Blood] 2013 Oct 31; Vol. 122 (18), pp. 3210-9. Date of Electronic Publication: 2013 Sep 06. - Publication Year :
- 2013
-
Abstract
- In thrombophilic families, protein S deficiency is clearly associated with venous thrombosis. We aimed to determine whether the same holds true in a population-based case-control study (n = 5317). Subjects were regarded protein S deficient when protein S levels were < 2.5th percentile of the controls. Free and total protein S deficiency was not associated with venous thrombosis: free protein S < 53 U/dL, odds ratio [OR] 0.82 (95% confidence interval [CI], 0.56-1.21) and total protein S < 68 U/dL, OR 0.90 (95% CI, 0.62-1.31). When lower cutoff values were applied, it appeared that subjects at risk of venous thrombosis could be identified at levels < 0.10th percentile of free protein S (< 33 U/dL, OR 5.4; 95% CI, 0.61-48.8). In contrast, even extremely low total protein S levels were not associated with venous thrombosis. PROS1 was sequenced in 48 subjects with free protein S level < 1st percentile (< 4 6 U/dL), and copy number variations were investigated in 2718 subjects, including all subjects with protein S (free or total) < 2.5th percentile. Mutations in PROS1 were detected in 5 patients and 5 controls reinforcing the observation that inherited protein S deficiency is rare in the general population. Protein S testing and PROS1 testing should not be considered in unselected patients with venous thrombosis.
- Subjects :
- Adult
Aged
Case-Control Studies
DNA Copy Number Variations
Female
Humans
Male
Middle Aged
Mutation
Odds Ratio
Protein S genetics
Protein S Deficiency blood
Protein S Deficiency genetics
Risk Assessment
Risk Factors
Sequence Analysis, DNA
Venous Thrombosis blood
Protein S metabolism
Protein S Deficiency metabolism
Venous Thrombosis metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1528-0020
- Volume :
- 122
- Issue :
- 18
- Database :
- MEDLINE
- Journal :
- Blood
- Publication Type :
- Academic Journal
- Accession number :
- 24014240
- Full Text :
- https://doi.org/10.1182/blood-2013-04-499335