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Is the image quality of I-124-PET impaired by an automatic correction of prompt gammas?
- Source :
-
PloS one [PLoS One] 2013 Aug 27; Vol. 8 (8), pp. e71729. Date of Electronic Publication: 2013 Aug 27 (Print Publication: 2013). - Publication Year :
- 2013
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Abstract
- Objectives: The aim of this study is to evaluate the quality of I-124 PET images with and without prompt gamma compensation (PGC) by comparing the recovery coefficients (RC), the signal to noise ratios (SNR) and the contrast to F-18 and Ga-68. Furthermore, the influence of the PGC on the quantification and image quality is evaluated.<br />Methods: For measuring the image quality the NEMA NU2-2001 PET/SPECT-Phantom was used containing 6 spheres with a diameter between 10 mm and 37 mm placed in water with different levels of background activity. Each sphere was filled with the same activity concentration measured by an independently cross-calibrated dose calibrator. The "hot" sources were acquired with a full 3D PET/CT (Biograph mCT®, Siemens Medical USA). Acquisition times were 2 min for F-18 and Ga-68, and 10 min for I-124. For reconstruction an OSEM algorithm was applied. For I-124 the images were reconstructed with and without PGC. For the calculation of the RCs the activity concentrations in each sphere were determined; in addition, the influence of the background correction was studied.<br />Results: The RCs of Ga-68 are the smallest (79%). I-124 reaches similar RCs (87% with PGC, 84% without PGC) as F-18 (84%). showing that the quantification of I-124 images is similar to F-18 and slightly better than Ga-68. With background activity the contrast of the I-124 PGC images is similar to Ga-68 and F-18 scans. There was lower background activity in the I-124 images without PGC, which probably originates from an overcorrection of the scatter contribution. Consequently, the contrast without PGC was much higher than with PGC. As a consequence PGC should be used for I-124.<br />Conclusions: For I-124 there is only a slight influence on the quantification depending on the use of the PGC. However, there are considerable differences with respect to I-124 image quality.
- Subjects :
- Fluorine Radioisotopes chemistry
Gallium Radioisotopes chemistry
Iodine Radioisotopes chemistry
Phantoms, Imaging
Radiopharmaceuticals chemistry
Reference Standards
Signal-To-Noise Ratio
Tomography, Emission-Computed, Single-Photon standards
Image Processing, Computer-Assisted standards
Positron-Emission Tomography standards
Subjects
Details
- Language :
- English
- ISSN :
- 1932-6203
- Volume :
- 8
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- PloS one
- Publication Type :
- Academic Journal
- Accession number :
- 24014105
- Full Text :
- https://doi.org/10.1371/journal.pone.0071729