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Clinical nanomedicine: a solution to the chemotherapy conundrum in pediatric leukemia therapy.
- Source :
-
Clinical pharmacology and therapeutics [Clin Pharmacol Ther] 2014 Feb; Vol. 95 (2), pp. 168-78. Date of Electronic Publication: 2013 Sep 05. - Publication Year :
- 2014
-
Abstract
- Although chemotherapy-based treatment of leukemia has tremendously improved survival rates in children, induction of treatment-related side effects is a major concern in clinical oncology. The development of nanotechnology-based drug delivery techniques to target clinically approved anticancer agents specifically to leukemic cells should diminish toxic side effects. This review aims to address the rational design of nanotherapeutics in treating hematologic malignancies with a focus on acute lymphoblastic leukemia (ALL)--the most prominent form of pediatric cancer.
- Subjects :
- Adolescent
Antineoplastic Agents administration & dosage
Antineoplastic Agents adverse effects
Child
Drug Carriers pharmacokinetics
Drug Carriers therapeutic use
Drug Delivery Systems methods
Humans
Precursor Cell Lymphoblastic Leukemia-Lymphoma drug therapy
Antineoplastic Agents therapeutic use
Leukemia drug therapy
Nanomedicine methods
Subjects
Details
- Language :
- English
- ISSN :
- 1532-6535
- Volume :
- 95
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Clinical pharmacology and therapeutics
- Publication Type :
- Academic Journal
- Accession number :
- 24013811
- Full Text :
- https://doi.org/10.1038/clpt.2013.174