Enhanced glucagon-like peptide-1 secretion in a patient with glucagonoma: implications for glucagon-like peptide-1 secretion from pancreatic α cells in vivo.

Authors :: Yabe D
Rokutan M
Miura Y
Komoto I
Usui R
Kuwata H
Watanabe K
Hyo T
Kurose T
Nagamatsu T
Shimizu S
Kawai J
Imamura M
Seino Y
Source :: Diabetes research and clinical practice [Diabetes Res Clin Pract] 2013 Oct; Vol. 102 (1), pp. e1-4. Date of Electronic Publication: 2013 Aug 19.
Publication Year :: 2013
Abstract: We examined GLP-1 secretion from the pancreas of a patient with glucagonoma and pancreatic resection by measuring GLP-1 after meal ingestion or selective arterial calcium injection, and immunohistochemical analysis. Our findings support the notion that GLP-1 is secreted from pancreatic α cells in humans.<br /> (Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.)

Subjects :: Adult
Arteries
Calcium Gluconate administration & dosage
Food
Glucagon blood
Glucagonoma surgery
Humans
Injections, Intra-Arterial
Male
Middle Aged
Multiple Endocrine Neoplasia Type 1 complications
Pancreatectomy
Glucagon-Like Peptide 1 metabolism
Glucagon-Secreting Cells metabolism
Glucagonoma metabolism

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