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High-dose therapy with autologous stem cell support for lymphoma--from experimental to standard treatment.
- Source :
-
Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke [Tidsskr Nor Laegeforen] 2013 Sep 03; Vol. 133 (16), pp. 1735-9. - Publication Year :
- 2013
-
Abstract
- High-dose therapy with autologous stem cell support (HDT) has been a therapeutic option for lymphomas in Norway since as far back as 1987. By restoring bone marrow function through reinfusion of the patient's own stem cells, it is possible to administer cancer treatment in higher and otherwise lethal doses, and thereby achieve better treatment results. Originally stem cells were harvested from bone marrow and the high-dose therapy included total body irradiation, but since the mid 1990s stem cells have been harvested by apheresis and the high-dose therapy has consisted of chemotherapy alone (BEAM chemotherapy). In 1995 the treatment was regionalised and since then it has been performed in all health regions. The HDT procedure was introduced as an experimental treatment in clinical studies with international collaboration. The indications have changed over time, and this is now established treatment for a number of types of lymphoma.
- Subjects :
- Antineoplastic Combined Chemotherapy Protocols therapeutic use
Combined Modality Therapy history
Critical Pathways
History, 20th Century
Humans
Lymphoma history
Norway
Practice Guidelines as Topic
Transplantation, Autologous history
Antineoplastic Combined Chemotherapy Protocols history
Hematopoietic Stem Cell Transplantation history
Lymphoma therapy
Subjects
Details
- Language :
- English; Norwegian
- ISSN :
- 0807-7096
- Volume :
- 133
- Issue :
- 16
- Database :
- MEDLINE
- Journal :
- Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke
- Publication Type :
- Academic Journal
- Accession number :
- 24005713
- Full Text :
- https://doi.org/10.4045/tidsskr.13.0319