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Identification of sturgeon IgD bridges the evolutionary gap between elasmobranchs and teleosts.
- Source :
-
Developmental and comparative immunology [Dev Comp Immunol] 2014 Feb; Vol. 42 (2), pp. 138-47. Date of Electronic Publication: 2013 Aug 31. - Publication Year :
- 2014
-
Abstract
- IgD has been found in almost all jawed vertebrates, including cartilaginous and teleost fish. However, IgD is missing in acipenseriformes, a branch that is evolutionarily positioned between elasmobranchs and teleost fish. Here, by analyzing transcriptome data, we identified a transcriptionally active IgD-encoding gene in the Siberian sturgeon (Acipenser baerii). Phylogenetic analysis indicated that it is orthologous to mammalian IgD and closely related to the IgD of other fish. The lengths of sturgeon membrane-bound IgD transcripts ranged from 1.2kb to 6.2kb, encoding 3-19 CH domains. As in teleosts, the first CH domain of the sturgeon IgD transcript is also derived from μCH1 by RNA splicing. However, the variable region of the expressed sturgeon IgD shows limited V(D)J usage. In addition to IgD, three IgM variants were also identified in this species, whereas no IgT/Z-encoding genes were observed. This study bridges the gap in Ig evolution between elasmobranchs and teleosts and provides significant insight into the early evolution of immunoglobulins.<br /> (Crown Copyright © 2013. Published by Elsevier Ltd. All rights reserved.)
- Subjects :
- Amino Acid Sequence
Animals
Base Sequence
Elasmobranchii immunology
Fish Proteins
Gene Expression Profiling
Genetic Variation
Immunoglobulin D immunology
Immunoglobulin Heavy Chains genetics
Immunoglobulin M immunology
Immunoglobulins deficiency
Immunoglobulins genetics
Phylogeny
RNA Splicing
Sequence Alignment
Sequence Analysis, DNA
Transcriptome genetics
Biological Evolution
Elasmobranchii genetics
Immunoglobulin D genetics
Immunoglobulin M genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1879-0089
- Volume :
- 42
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Developmental and comparative immunology
- Publication Type :
- Academic Journal
- Accession number :
- 24001581
- Full Text :
- https://doi.org/10.1016/j.dci.2013.08.020