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The cytotoxicity of 8-O-4' neolignans from the seeds of Crataegus pinnatifida.
- Source :
-
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2013 Oct 15; Vol. 23 (20), pp. 5599-604. Date of Electronic Publication: 2013 Aug 17. - Publication Year :
- 2013
-
Abstract
- Nine new 8-O-4' neolignans, named pinnatifidanin B I-IX (1-9), together with 9 known analogs (10-18) were isolated from the seeds of Crataegus pinnatifida. The structures of 1-18 were determined by spectroscopic methods, including 1D, 2D NMR, CD and HRESIMS analysis. Compounds 8-11, 17 and 18 displayed potent cytotoxic activities against human cancer cell lines, and most interestingly, none of the 6 compounds displayed inhibitory activity against human lung cell line (Mrc5). The 6 cytotoxic compounds are considered to be potential as antitumor agents, which could significantly inhibit the cancer cell growth in a dose-dependent manner and are probably safer than positive control drug.<br /> (Copyright © 2013 Elsevier Ltd. All rights reserved.)
- Subjects :
- Antineoplastic Agents, Phytogenic isolation & purification
Antineoplastic Agents, Phytogenic toxicity
Cell Line, Tumor
Cell Survival drug effects
Circular Dichroism
Crataegus metabolism
Drug Screening Assays, Antitumor
Humans
Lignans isolation & purification
Lignans toxicity
Magnetic Resonance Spectroscopy
Molecular Conformation
Seeds chemistry
Seeds metabolism
Antineoplastic Agents, Phytogenic chemistry
Crataegus chemistry
Lignans chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1464-3405
- Volume :
- 23
- Issue :
- 20
- Database :
- MEDLINE
- Journal :
- Bioorganic & medicinal chemistry letters
- Publication Type :
- Academic Journal
- Accession number :
- 23999046
- Full Text :
- https://doi.org/10.1016/j.bmcl.2013.08.045