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[Identification and evaluation of the neuroleptic activity of phenotropil].
- Source :
-
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova [Zh Nevrol Psikhiatr Im S S Korsakova] 2013; Vol. 113 (7), pp. 42-6. - Publication Year :
- 2013
-
Abstract
- The neuroleptic (antipsychotic) activity of phenotropil was studied in an experimental animal model. Phenotropil had a marked neuroleptic activity in models of positive (apomorphine-induced verticalization test) and negative (5-HTP-induced hyperkinesis test) symptoms of psychoses as well as in the m-cholinergic pathway hyperactivation (arecoline-induced tremor test). The compound markedly antagonized haloperidol catalepsy. Used in a single dose or as a course treatment, phenotropil did not provoke aggression nor intensify it. In contrast to typical and atypical antipsychotics, phenotropil had no sedative action and other adverse effects. It exhibited a positive effect on exploratory behavior and motor activity, had anxiolytic and antidepressant action.
- Subjects :
- Animals
Antipsychotic Agents pharmacokinetics
Antipsychotic Agents therapeutic use
Disease Models, Animal
Male
Mice
Motor Activity drug effects
Piracetam pharmacokinetics
Piracetam therapeutic use
Psychotic Disorders metabolism
Rats
Treatment Outcome
Piracetam analogs & derivatives
Psychotic Disorders drug therapy
Subjects
Details
- Language :
- Russian
- ISSN :
- 1997-7298
- Volume :
- 113
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova
- Publication Type :
- Academic Journal
- Accession number :
- 23994920