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Effect of diclofenac and glycol intercalation on structural assembly of phospholipid lamellar vesicles.

Authors :
Castangia I
Manca ML
Matricardi P
Sinico C
Lampis S
Fernàndez-Busquets X
Fadda AM
Manconi M
Source :
International journal of pharmaceutics [Int J Pharm] 2013 Nov 01; Vol. 456 (1), pp. 1-9. Date of Electronic Publication: 2013 Aug 27.
Publication Year :
2013

Abstract

The aim of the current study was to improve the knowledge of drug-glycol-phospholipid-interactions and their effects in lamellar vesicle suitability as drug delivery systems. Liposomes were prepared using hydrogenated soy phosphatidylcholine (P90H, 60 mg/ml) and diclofenac sodium salt at two concentrations (5-10 mg/ml). To obtain innovative vesicles two permeation enhancers with glycol group, diethyleneglycol monoethyl ether and propylene glycol, were added to the water phase at different ratios (5%, 10%, and 20%). Vesicle organization was deeply investigated by physico-chemical characterization, including differential scanning calorimetry and small-angle diffraction signal analysis while macroscopic structure behavior was evaluated by rheological studies. Results evidenced that the presence of the penetration enhancer and diclofenac sodium salt led to structural rearrangements within and among vesicles forming a tridimensional and complex architecture in which vesicles were closely packed and interconnected. This new design allowed a change in the physical state of dispersions that became highly viscous liquid or soft-solid-like, thus forming an ideal system for topical application able of both adhering to the skin and delivering the drug.<br /> (Copyright © 2013 Elsevier B.V. All rights reserved.)

Details

Language :
English
ISSN :
1873-3476
Volume :
456
Issue :
1
Database :
MEDLINE
Journal :
International journal of pharmaceutics
Publication Type :
Academic Journal
Accession number :
23994760
Full Text :
https://doi.org/10.1016/j.ijpharm.2013.08.034