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Influence of aripiprazole pretreatment on the reinforcing effects of methamphetamine in humans.
- Source :
-
Progress in neuro-psychopharmacology & biological psychiatry [Prog Neuropsychopharmacol Biol Psychiatry] 2013 Dec 02; Vol. 47, pp. 111-7. Date of Electronic Publication: 2013 Aug 28. - Publication Year :
- 2013
-
Abstract
- Methamphetamine use disorders remain a significant public health concern. Methamphetamine produces its behavioral effects by facilitating release of monoamines like dopamine (DA) and serotonin (5-HT). Results from animal studies show that acute pretreatment with DA and 5-HT antagonists attenuates the effects of methamphetamine, but this area remains largely unexplored in humans. This study sought to assess whether aripiprazole, a partial agonist at D2/5-HT1A receptors and an antagonist at 5-HT2A receptors, would attenuate the reinforcing and subject-rated effects of oral methamphetamine. Seven subjects with histories of recreational stimulant use completed a placebo-controlled, crossover, double-blind protocol in which they first sampled doses of oral methamphetamine (0, 4, 8 or 16 mg) following acute pretreatment with aripiprazole (0 and 15 mg). During each Sampling Session, subjects also completed a battery of subject-rated, cardiovascular, and other performance measures. In subsequent Self-Administration Sessions, subjects were provided the opportunity to earn the previously sampled methamphetamine dose on a progressive-ratio procedure. Methamphetamine functioned as a reinforcer, and produced prototypical stimulant-like subject-rated and cardiovascular effects (e.g., increased ratings of Stimulated; elevated blood pressure). Aripiprazole reduced methamphetamine self-administration and attenuated some of the positive subject-rated effects of methamphetamine (e.g., ratings of Like Drug). These results indicate that acute aripiprazole pretreatment attenuates the abuse-related effects of methamphetamine.<br /> (© 2013.)
- Subjects :
- Adult
Analysis of Variance
Aripiprazole
Blood Pressure drug effects
Dose-Response Relationship, Drug
Drug Administration Schedule
Female
Heart Rate drug effects
Humans
Male
Methamphetamine adverse effects
Reinforcement, Psychology
Self Administration
Surveys and Questionnaires
Young Adult
Antipsychotic Agents administration & dosage
Central Nervous System Stimulants administration & dosage
Methamphetamine administration & dosage
Piperazines administration & dosage
Quinolones administration & dosage
Substance-Related Disorders etiology
Substance-Related Disorders prevention & control
Subjects
Details
- Language :
- English
- ISSN :
- 1878-4216
- Volume :
- 47
- Database :
- MEDLINE
- Journal :
- Progress in neuro-psychopharmacology & biological psychiatry
- Publication Type :
- Academic Journal
- Accession number :
- 23994622
- Full Text :
- https://doi.org/10.1016/j.pnpbp.2013.08.007