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Ki-67 overexpression in WHO grade II gliomas is associated with poor postoperative seizure control.
- Source :
-
Seizure [Seizure] 2013 Dec; Vol. 22 (10), pp. 877-81. Date of Electronic Publication: 2013 Aug 12. - Publication Year :
- 2013
-
Abstract
- Purpose: Seizures are the most common initial symptom in patients with low-grade gliomas, and approximately 30% of these patients still suffer from epilepsy after gross-total resection of the tumour. We examined the relationship between the overexpression of ki-67 in WHO grade II gliomas and seizure control.<br />Methods: A series of 93 histologically confirmed WHO grade II glioma tissues were analysed through immunohistochemical staining for ki-67 expression. Follow-up visits regarding seizure control were scheduled at 12 months. The Engel classification was used to categorise patients' seizure status.<br />Results: Of the 93 patients analysed, 65 (66.3%) patients initially presented with seizures. A total of 36 patients were diagnosed with WHO grade II oligodendrogliomas, 29 patients had oligoastrocytomas and 28 patients had astrocytomas. Ki-67 was over-expressed in 15 patients. One year after surgery poor seizure control was observed in 11 of these patients. In contrast, low ki-67 expression (<10%) was found in 78 patients. Poor seizure control was observed in 36 patients (difference between ki-67 over- and low expression groups P = 0.002). Logistic regression analysis revealed that patients with gross-total resection achieved better seizure control while ki-67 overexpression and age below 38 years were poor seizure control factors explained of the variance of seizure outcome (OR: 0.382, 4.354 and 1.822, respectively).<br />Conclusions: In WHO grade II gliomas, Ki-67 is a molecular marker which predicts poor seizure control of glioma patients after the resection of the tumour. Gross-total resection, ki-67 overexpression and age below 38 years significantly affect seizure prognosis.<br /> (Copyright © 2013 British Epilepsy Association. Published by Elsevier Ltd. All rights reserved.)
- Subjects :
- Adult
Brain Neoplasms complications
Brain Neoplasms pathology
Brain Neoplasms surgery
Female
Glioma complications
Glioma pathology
Glioma surgery
Humans
Male
Middle Aged
Neoplasm Grading
Postoperative Period
Prognosis
Seizures etiology
Seizures pathology
Treatment Outcome
Brain Neoplasms metabolism
Glioma metabolism
Ki-67 Antigen metabolism
Seizures surgery
Subjects
Details
- Language :
- English
- ISSN :
- 1532-2688
- Volume :
- 22
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Seizure
- Publication Type :
- Academic Journal
- Accession number :
- 23992787
- Full Text :
- https://doi.org/10.1016/j.seizure.2013.08.004