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[Analysis of therapeutic effect and prognosis in patients with metastatic colorectal cancer and different K-ras status].
- Source :
-
Zhonghua zhong liu za zhi [Chinese journal of oncology] [Zhonghua Zhong Liu Za Zhi] 2013 Apr; Vol. 35 (4), pp. 273-6. - Publication Year :
- 2013
-
Abstract
- Objective: To evaluate the correlation of clinical effect and prognosis between patients with metastatic colorectal cancer (mCRC) and different K-ras status.<br />Methods: The clinical characteristics, chemotherapeutic regimens and survival of 153 mCRC patients with different K-ras status were analyzed retrospectively.<br />Results: The median overall survival (OS) in patients without K-ras mutation were 31.7 months, significantly longer than 21.3 months in the patients with K-ras mutation (P = 0.037). The median progression-free survival (PFS) and OS in patients who received chemotherapy followed by anti-EGFR antibody treatment were 11.5 and 39.3 months, respectively, significantly longer as compared with the PFS and OS in those received chemotherapy in combination with anti-EGFR antibody concomitantly (5.7, P = 0.02, and 28.7 months, P = 0.034, respectively).<br />Conclusions: K-ras status is a prognostic biomarker for mCRC patients treated with anti-EGFR antibody. The combination settings of anti-EGFR in combination with chemotherapy may improve survival of mCRC patients with wild-type K-ras status.
- Subjects :
- Aged
Antineoplastic Agents therapeutic use
Antineoplastic Agents, Phytogenic therapeutic use
Camptothecin analogs & derivatives
Camptothecin therapeutic use
Colorectal Neoplasms pathology
Colorectal Neoplasms surgery
Combined Modality Therapy
Disease-Free Survival
Female
Follow-Up Studies
Humans
Irinotecan
Liver Neoplasms secondary
Liver Neoplasms therapy
Lung Neoplasms secondary
Lung Neoplasms therapy
Male
Middle Aged
Mutation
Organoplatinum Compounds therapeutic use
Oxaliplatin
Retrospective Studies
Survival Rate
Antibodies, Monoclonal therapeutic use
Colorectal Neoplasms genetics
Colorectal Neoplasms therapy
ErbB Receptors immunology
Genes, ras
Subjects
Details
- Language :
- Chinese
- ISSN :
- 0253-3766
- Volume :
- 35
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Zhonghua zhong liu za zhi [Chinese journal of oncology]
- Publication Type :
- Academic Journal
- Accession number :
- 23985255
- Full Text :
- https://doi.org/10.3760/cma.j.issn.0253-3766.2013.04.007