Peptide amphiphile nanoparticles enhance the immune response against a CpG-adjuvanted influenza antigen.

Authors :: Zope H
Quer CB
Bomans PH
Sommerdijk NA
Kros A
Jiskoot W
Source :: Advanced healthcare materials [Adv Healthc Mater] 2014 Mar; Vol. 3 (3), pp. 343-8. Date of Electronic Publication: 2013 Aug 27.
Publication Year :: 2014
Abstract: Cationic peptide amphiphile nanoparticles are employed for co-delivery of immune modulator CpG and antigen. This results in better targeting to the antigen presenting cells and eliciting strong Th1 response, which is effective against the intracellular pathogens.<br /> (© 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)

Subjects :: Animals
Antibodies, Viral blood
Humans
Immunoglobulin G blood
Influenza, Human prevention & control
Mice, Inbred C57BL
Orthomyxoviridae Infections prevention & control
Vaccines immunology
Adjuvants, Immunologic pharmacology
Antigens, Viral immunology
CpG Islands
Nanoparticles chemistry
Peptides chemistry
Vaccines chemistry

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