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Arbidol inhibits viral entry by interfering with clathrin-dependent trafficking.
- Source :
-
Antiviral research [Antiviral Res] 2013 Oct; Vol. 100 (1), pp. 215-9. Date of Electronic Publication: 2013 Aug 25. - Publication Year :
- 2013
-
Abstract
- Arbidol (ARB) is a broad-spectrum antiviral displaying activity against a number of enveloped and non-enveloped viruses. It was described as a viral entry inhibitor and shown to interact at the molecular level with lipid membranes and viral fusion glycoproteins to impede viral entry and fusion. However its mechanism of action at the cellular level remains unknown. Here, by using live-cell confocal imaging and the hepatitis C virus as a model virus, we show that ARB affects clathrin-mediated endocytosis by impeding dynamin-2-induced membrane scission. Moreover it induces the intracellular accumulation of clathrin-coated structures where viral particles are trapped. Collectively, our results shed light on the mechanistic aspects of ARB antiviral activity and suggest that ARB could prevent cell infection by viruses that enter through clathrin-mediated endocytosis.<br /> (Copyright © 2013 Elsevier B.V. All rights reserved.)
- Subjects :
- Cell Line, Tumor
Down-Regulation drug effects
Dynamin II metabolism
Hepacivirus physiology
Hepatitis C drug therapy
Humans
Protein Transport drug effects
Antiviral Agents pharmacology
Clathrin metabolism
Endocytosis drug effects
Hepacivirus drug effects
Hepatitis C metabolism
Hepatitis C virology
Indoles pharmacology
Virus Internalization drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1872-9096
- Volume :
- 100
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Antiviral research
- Publication Type :
- Academic Journal
- Accession number :
- 23981392
- Full Text :
- https://doi.org/10.1016/j.antiviral.2013.08.008