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Possible mechanisms of neutrophil activation in Behçet's disease.
- Source :
-
International immunopharmacology [Int Immunopharmacol] 2013 Dec; Vol. 17 (4), pp. 1206-10. Date of Electronic Publication: 2013 Aug 23. - Publication Year :
- 2013
-
Abstract
- Behçet's disease (BD) is a systemic inflammatory disorder characterized by recurrent episodes of acute inflammation consisting mainly of neutrophil infiltration around blood vessels in affected tissues. BD probably occurs due to neutrophil-based innate immune responses orchestrated by a complex interplay among gamma-delta T lymphocytes, natural killer T cells, monocytes and Th17 lymphocytes in which type-I interferon is possibly a key element for inflammatory downregulation. However, strong evidence is still scarce. This article compiles the literature in an attempt to summarize the possible mechanisms by which neutrophils are activated in BD and suggests directions for future research.<br /> (© 2013 Elsevier B.V. All rights reserved.)
- Subjects :
- Animals
Granulocyte Colony-Stimulating Factor immunology
Granulocyte-Macrophage Colony-Stimulating Factor immunology
Humans
Interferon Type I immunology
Interleukin-8 immunology
Th17 Cells immunology
Toll-Like Receptors immunology
Behcet Syndrome immunology
Neutrophil Activation
Neutrophils immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1878-1705
- Volume :
- 17
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- International immunopharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 23973446
- Full Text :
- https://doi.org/10.1016/j.intimp.2013.07.017