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Liver function test abnormalities in Nigerian patients with human immunodeficiency virus and hepatitis B virus co-infection.
- Source :
-
International journal of STD & AIDS [Int J STD AIDS] 2013 Jun; Vol. 24 (6), pp. 461-7. Date of Electronic Publication: 2013 Jun 24. - Publication Year :
- 2013
-
Abstract
- Data on baseline hepatic function of HIV and hepatitis B virus (HBV) co-infected patients are limited in sub-Saharan Africa. We assessed liver function test (LFT) abnormalities in Nigerian patients with HIV/HBV co-infection to highlight the impact of HIV on HBV-related liver disease in sub-Saharan Africa. A cross-sectional study involving 100 HIV/HBV co-infected patients and 100 age- and sex-matched HBV mono-infected controls. Blood testing for HIV antibodies, CD4+ cell count, hepatitis B surface antigen (HBsAg), hepatitis B e antigen (HBeAg), LFTs, platelet count, fasting blood glucose and lipid profile were carried out. Non-invasive hepatic fibrosis scores (aspartate aminotransferase-platelet ratio index [APRI] and FIB-4) were also calculated. Co-infected patients had deranged liver enzymes more than the controls (77% versus 64%, P = 0.04). The predominant patterns of enzyme derangement in co-infected patients were either predominantly ↑ALP (30% versus 4%, P < 0.0001) or mixed (30% versus 15%, P = 0.01) but predominantly ↑AST/ALT in the controls (25% versus 9%, P = 0.003). Co-infected patients had higher fibrosis scores for both APRI (P = 0.002) and FIB-4 (P = 0.0001). On further analysis, LFT abnormalities and fibrosis scores were only significantly higher in co-infected patients in the immune clearance and HBeAg-negative chronic hepatitis phases. LFT abnormalities are common in Nigerians with HBV infection and co-infection with HIV negatively impacts on hepatic function.
- Subjects :
- Adult
Biomarkers blood
CD4 Lymphocyte Count
Case-Control Studies
Cross-Sectional Studies
Enzyme-Linked Immunosorbent Assay
Female
HIV Infections blood
HIV Infections virology
HIV Seronegativity
Hepatitis B blood
Hepatitis B virology
Hepatitis B virus isolation & purification
Hospitals, Teaching
Humans
Liver immunology
Liver virology
Male
Middle Aged
Nigeria
Socioeconomic Factors
Viral Load
Coinfection
HIV Infections complications
Hepatitis B complications
Hepatitis B Surface Antigens blood
Liver Function Tests methods
Subjects
Details
- Language :
- English
- ISSN :
- 1758-1052
- Volume :
- 24
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- International journal of STD & AIDS
- Publication Type :
- Academic Journal
- Accession number :
- 23970749
- Full Text :
- https://doi.org/10.1177/0956462412473889