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Regulatory mechanisms for glycogenolysis and K+ uptake in brain astrocytes.
- Source :
-
Neurochemistry international [Neurochem Int] 2013 Nov; Vol. 63 (5), pp. 458-64. Date of Electronic Publication: 2013 Aug 19. - Publication Year :
- 2013
-
Abstract
- Recent advances in brain energy metabolism support the notion that glycogen in astrocytes is necessary for the clearance of neuronally-released K(+) from the extracellular space. However, how the multiple metabolic pathways involved in K(+)-induced increase in glycogen turnover are regulated is only partly understood. Here we summarize the current knowledge about the mechanisms that control glycogen metabolism during enhanced K(+) uptake. We also describe the action of the ubiquitous Na(+)/K(+) ATPase for both ion transport and intracellular signaling cascades, and emphasize its importance in understanding the complex relation between glycogenolysis and K(+) uptake.<br /> (Copyright © 2013 Elsevier Ltd. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1872-9754
- Volume :
- 63
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Neurochemistry international
- Publication Type :
- Academic Journal
- Accession number :
- 23968961
- Full Text :
- https://doi.org/10.1016/j.neuint.2013.08.004