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Angiogenic factors in relation to clinical effect in a phase II trial of weekly paclitaxel.
- Source :
-
Breast (Edinburgh, Scotland) [Breast] 2013 Dec; Vol. 22 (6), pp. 1142-7. Date of Electronic Publication: 2013 Aug 20. - Publication Year :
- 2013
-
Abstract
- Background: Several anticancer agents including paclitaxel have an inhibitory effect on angiogenesis.<br />Aims: To compare the overall response rate and time to progression with changes in circulating angiogenic factors during palliative treatment with weekly paclitaxel.<br />Material and Methods: Patients with metastatic BC, ECOG 0-2, received weekly paclitaxel, concomitant with trastuzumab if HER2+ BC (n = 7). Circulating vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) were determined at base-line and before start of new course.<br />Results: Fifty-five of 63 included patients were evaluable. The overall response rate including stable disease ≥24 weeks (CR + PD + SD) was obtained in 25 of the evaluable patients (45%). The median time to progression (TTP) was 5.3 months and overall survival (OS) 16.7 months. Patients with triple negative breast cancer (TNBC) showed a trend towards higher base-line VEGF compared with hormone receptor positive or HER2+ tumours and had shorter TTP. Significant differences in VEGF and bFGF levels at 12 weeks were found between patients with longer versus shorter TTP (VEGF: p = 0.046, bFGF: p = 0.005) and between patients gaining versus lacking clinical benefit (VEGF: p = 0.05, bFGF: p = 0.02).<br />Conclusions: The clinical utility of circulating VEGF may be a useful tool for monitoring treatment efficacy.<br /> (Copyright © 2013 Elsevier Ltd. All rights reserved.)
- Subjects :
- Adult
Aged
Antibodies, Monoclonal, Humanized administration & dosage
Antineoplastic Combined Chemotherapy Protocols adverse effects
Breast Neoplasms chemistry
Disease Progression
Disease-Free Survival
Female
Humans
Middle Aged
Paclitaxel administration & dosage
Paclitaxel adverse effects
Receptor, ErbB-2 analysis
Time Factors
Trastuzumab
Triple Negative Breast Neoplasms blood
Triple Negative Breast Neoplasms drug therapy
Antineoplastic Combined Chemotherapy Protocols therapeutic use
Breast Neoplasms blood
Breast Neoplasms drug therapy
Fibroblast Growth Factor 2 blood
Paclitaxel therapeutic use
Vascular Endothelial Growth Factor A blood
Subjects
Details
- Language :
- English
- ISSN :
- 1532-3080
- Volume :
- 22
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Breast (Edinburgh, Scotland)
- Publication Type :
- Academic Journal
- Accession number :
- 23968864
- Full Text :
- https://doi.org/10.1016/j.breast.2013.07.041