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Variants in HAVCR1 gene region contribute to hepatitis C persistence in African Americans.
- Source :
-
The Journal of infectious diseases [J Infect Dis] 2014 Feb 01; Vol. 209 (3), pp. 355-9. Date of Electronic Publication: 2013 Aug 20. - Publication Year :
- 2014
-
Abstract
- To confirm previously identified polymorphisms in HAVCR1 that were associated with persistent hepatitis C virus (HCV) infection in individuals of African and of European descent, we studied 165 subjects of African descent and 635 subjects of European descent. Because the association was only confirmed in subjects of African descent (rs6880859; odds ratio, 2.42; P = .01), we then used 379 subjects of African descent (142 with spontaneous HCV clearance) to fine-map HAVCR1. rs111511318 was strongly associated with HCV persistence after adjusting for IL28B and HLA (adjusted P = 8.8 × 10(-4)), as was one 81-kb haplotype (adjusted P = .0006). The HAVCR1 genomic region is an independent genetic determinant of HCV persistence in individuals of African descent.
Details
- Language :
- English
- ISSN :
- 1537-6613
- Volume :
- 209
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- The Journal of infectious diseases
- Publication Type :
- Academic Journal
- Accession number :
- 23964107
- Full Text :
- https://doi.org/10.1093/infdis/jit444