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microRNA control of interferons and interferon induced anti-viral activity.
- Source :
-
Molecular immunology [Mol Immunol] 2013 Dec; Vol. 56 (4), pp. 781-93. Date of Electronic Publication: 2013 Aug 23. - Publication Year :
- 2013
-
Abstract
- Interferons (IFNs) are cytokines that are spontaneously produced in response to virus infection. They act by binding to IFN-receptors (IFN-R), which trigger JAK/STAT cell signalling and the subsequent induction of hundreds of IFN-inducible genes, including both protein-coding and microRNA genes. IFN-induced genes then act synergistically to prevent virus replication and create an anti-viral state. miRNA are therefore integral to the innate response to virus infection and are important components of IFN-mediated biology. On the other hand viruses also encode miRNAs that in some cases interfere directly with the IFN response to infection. This review summarizes the important roles of miRNAs in virus infection acting both as IFN-stimulated anti-viral molecules and as critical regulators of IFNs and IFN-stimulated genes. It also highlights how recent knowledge in RNA editing influence miRNA control of virus infection.<br /> (Copyright © 2013 Elsevier Ltd. All rights reserved.)
- Subjects :
- 3' Untranslated Regions genetics
Antiviral Agents pharmacology
Gene Expression Regulation drug effects
Gene Expression Regulation genetics
Humans
Interferons metabolism
MicroRNAs genetics
Models, Genetic
RNA, Messenger genetics
RNA, Messenger metabolism
Virus Diseases genetics
Virus Diseases virology
Interferons therapeutic use
MicroRNAs metabolism
Virus Diseases drug therapy
Virus Replication drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1872-9142
- Volume :
- 56
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Molecular immunology
- Publication Type :
- Academic Journal
- Accession number :
- 23962477
- Full Text :
- https://doi.org/10.1016/j.molimm.2013.07.009