Back to Search
Start Over
[C-reactive protein prior to radical cystectomy: preoperative determination of CRP].
- Source :
-
Der Urologe. Ausg. A [Urologe A] 2014 Feb; Vol. 53 (2), pp. 222-7. - Publication Year :
- 2014
-
Abstract
- Background: Numerous studies have shown a positive correlation between elevated C-reactive protein (CRP) and systemic spread of malignancies. The goal of the current study was to assess the predictive significance of preoperative CRP in patients undergoing radical cystectomy (RC).<br />Material and Methods: Preoperative CRP values were measured in 194 patients undergoing RC because of urothelial carcinoma between 1996 and 2005. Elevated CRP level was defined as ≥ 5 mg/l.<br />Results: Preoperative increased CRP values were detected in 89 (45.9%) patients and these patients were more likely to have advanced tumor stages (pT3-4), positive resection margins and positive lymph nodes. Advanced urinary diversions were more common in patients with normal CRP values. In multivariate analysis, CRP was identified as an independent prognostic indicator for poor cancer-specific survival.<br />Conclusion: The results confirm previous reports that showed a prognostic significance of preoperative CRP elevation.
- Subjects :
- Aged
Female
Germany
Humans
Male
Middle Aged
Preoperative Care methods
Preoperative Care mortality
Prevalence
Prognosis
Reproducibility of Results
Retrospective Studies
Risk Assessment
Sensitivity and Specificity
Survival Rate
Urinary Bladder Neoplasms surgery
Biomarkers, Tumor blood
C-Reactive Protein analysis
Cystectomy mortality
Preoperative Care statistics & numerical data
Urinary Bladder Neoplasms blood
Urinary Bladder Neoplasms mortality
Subjects
Details
- Language :
- German
- ISSN :
- 1433-0563
- Volume :
- 53
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Der Urologe. Ausg. A
- Publication Type :
- Academic Journal
- Accession number :
- 23955283
- Full Text :
- https://doi.org/10.1007/s00120-013-3299-x