Cell stress response in rat chronic small bowel allograft rejection.

Authors :: Wang J
Li Y
Li J
Source :: Transplantation proceedings [Transplant Proc] 2013 Jul-Aug; Vol. 45 (6), pp. 2539-42.
Publication Year :: 2013
Abstract: Background: We sought to assess the expression of five cell stress molecules: Heat shock protein (HSP)-60, HSP-70, interferon (IFN)-α, rat retinoic acid early induible-1 like transcript (RRLT), and vasoactive intestinal peptide (VIP) during rat chronic small bowel allograft rejection.<br />Methods: A rat model of small bowel allograft rejection was induced on postoperative day 90 using F344 rat as donor and Lewis rat as recipient.<br />Results: We demonstrated increased expression of lamina propria HSP-60 (mean rank grade 8.3 and 3.2, respectively), graft RRLT (relative mRNA amount 5.1 ± 1.8 and 3.0 ± 1.3, respectively) and IFN-α (relative mRNA amount 108.3 ± 49.2 and 59.2 ± 22.0, respectively) in allograft group compared with the isograft group.<br />Conclusion: These data suggest the presence of cell stress during chronic small bowel allograft rejection.<br /> (Copyright © 2013 Elsevier Inc. All rights reserved.)