Back to Search
Start Over
[Viral and drug-induced liver damage in children with tuberculosis: prevalence, clinical features].
- Source :
-
Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology [Eksp Klin Gastroenterol] 2013 (1), pp. 38-43. - Publication Year :
- 2013
-
Abstract
- Unlabelled: THE AIM OF THE RESEARCH: Improving the effectiveness of diagnostics and treatment of viral and drug-induced lesions of the liver (DILL) at a tuberculosis in children by identifying the frequency of their distribution, peculiarities of diagnostics and clinics.<br />Materials and Methods: We examined 242 children in the age from 2 months to 17 years, the patients with different forms of tuberculosis.<br />Results: The prevalence of hepatitis in children with tuberculosis: B - 1,2%, C-0.4%, G - 4,6%, TT - 8,7%. DILL was diagnosed in 67.5% of children - TB patients, in 48% of the children with DILL an asymptomatic course of the disease was noted, however, in 54.4% of the children with DILL cytolitic syndrome was expressed (ALT> standards).<br />Conclusion: The prevalence of viral hepatitis B and C among children with TB is low. The infection with viruses of hepatitis G and TT is more often, but has no significant impact as on the course of tuberculosis, and on the severity of the liver damage. Drug-induced liver damage is a dominant view of pathology of the liver in children - TB patients and is mostly asymptomatic, but with a pronounced cytolitic syndrome.
- Subjects :
- Adolescent
Antitubercular Agents administration & dosage
Antitubercular Agents adverse effects
Antitubercular Agents therapeutic use
Biomarkers blood
Chemical and Drug Induced Liver Injury diagnosis
Chemical and Drug Induced Liver Injury epidemiology
Child
Child, Preschool
Hepatitis Antigens blood
Hepatitis, Viral, Human diagnosis
Hepatitis, Viral, Human epidemiology
Humans
Infant
Liver drug effects
Liver pathology
Liver Function Tests
Moscow
Prevalence
Tuberculosis diagnosis
Tuberculosis drug therapy
Tuberculosis epidemiology
Chemical and Drug Induced Liver Injury complications
Hepatitis, Viral, Human complications
Tuberculosis complications
Subjects
Details
- Language :
- Russian
- ISSN :
- 1682-8658
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology
- Publication Type :
- Academic Journal
- Accession number :
- 23951897