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Prognostic value of preoperative 18F-FDG PET/CT for primary head and neck squamous cell carcinoma.
- Source :
-
European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery [Eur Arch Otorhinolaryngol] 2014 Jun; Vol. 271 (6), pp. 1685-91. Date of Electronic Publication: 2013 Aug 15. - Publication Year :
- 2014
-
Abstract
- (18)F-FDG PET/CT is clinically useful in the initial staging and follow-up of patients with head and neck squamous cell carcinoma (HNSCC). We studied the potential prognostic significance of preoperative (18)F-FDG PET/CT in HNSCC. The medical records of 294 patients who underwent preoperative (18)F-FDG PET/CT for HNSCC were retrospectively reviewed. The median SUVmax of the primary lesions (SUVmax-p) and cervical lymph nodes (SUVmax-n) was 7.98 ± 5.04 (range 1.2-28.7) and 3.34 ± 3.70 (range 1.0-20.4), respectively. There was a significant difference between with and without recurrence in SUVmax-p (11.14 ± 5.36 vs. 6.78 ± 4.35, p < 0.001) and SUVmax-n (5.60 ± 4.22 vs. 1.75 ± 1.46, p < 0.001). The cut-off values of SUVmax-p and SUVmax-n in the context of recurrence and cancer-related death were 8.5 and 3.5. The 5-year disease-free survival of patients with SUVmax-p < 8.5 and SUVmax-n < 3.5 was 79 and 79%, respectively, whereas that of patients with SUVmax-p ≥ 8.5 and SUVmax-n ≥ 3.5 was 39 and 30 %, respectively. Multivariate analysis confirmed the significant association between 5-year disease-free survival and SUVmax-p ≥ 8.5 (hazard ratio (HR) 2.68, p < 0.001) and SUVmax-n ≥ 3.5 (HR 2.29, p = 0.007). Furthermore, SUVmax-p ≥ 8.5 (HR 3.20, p = 0.012) and SUVmax-n ≥ 3.5 (HR 2.14, p < 0.001) were associated with 5-year overall survival. (18)F-FDG PET/CT cut-off values of SUVmax-p ≥ 8.5 or SUVmax-n ≥ 3.5 are associated with a recurrence and survival in HNSCC.
- Subjects :
- Adult
Aged
Aged, 80 and over
Carcinoma, Squamous Cell surgery
Cohort Studies
Disease-Free Survival
Female
Fluorodeoxyglucose F18
Head and Neck Neoplasms surgery
Humans
Laryngeal Neoplasms surgery
Male
Middle Aged
Mouth Neoplasms surgery
Multimodal Imaging
Multivariate Analysis
Neck
Pharyngeal Neoplasms surgery
Positron-Emission Tomography
Prognosis
Proportional Hazards Models
Radiopharmaceuticals
Retrospective Studies
Squamous Cell Carcinoma of Head and Neck
Tomography, X-Ray Computed
Young Adult
Carcinoma, Squamous Cell diagnostic imaging
Head and Neck Neoplasms diagnostic imaging
Laryngeal Neoplasms diagnostic imaging
Lymph Nodes diagnostic imaging
Mouth Neoplasms diagnostic imaging
Pharyngeal Neoplasms diagnostic imaging
Subjects
Details
- Language :
- English
- ISSN :
- 1434-4726
- Volume :
- 271
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
- Publication Type :
- Academic Journal
- Accession number :
- 23949547
- Full Text :
- https://doi.org/10.1007/s00405-013-2605-y