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Can noninvasive brain stimulation measure and modulate developmental plasticity to improve function in stroke-induced cerebral palsy?
- Source :
-
Seminars in pediatric neurology [Semin Pediatr Neurol] 2013 Jun; Vol. 20 (2), pp. 116-26. - Publication Year :
- 2013
-
Abstract
- The permanent nature of motor deficits is a consistent cornerstone of cerebral palsy definitions. Such pessimism is disheartening to children, families, and researchers alike and may no longer be appropriate for it ignores the fantastic plastic potential of the developing brain. Perinatal stroke is presented as the ideal human model of developmental neuroplasticity following distinct, well-defined, focal perinatal brain injury. Elegant animal models are merging with human applied technology methods, including noninvasive brain stimulation for increasingly sophisticated models of plastic motor development following perinatal stroke. In this article, how potential central therapeutic targets are identified and potentially modulated to enhance motor function within these models is discussed. Also, future directions and emerging clinical trials are reviewed.<br /> (Copyright © 2013 Elsevier Inc. All rights reserved.)
- Subjects :
- Cerebral Palsy physiopathology
Humans
Models, Neurological
Stroke physiopathology
Cerebral Palsy etiology
Cerebral Palsy rehabilitation
Electric Stimulation Therapy
Neuronal Plasticity physiology
Recovery of Function
Stroke complications
Stroke Rehabilitation
Transcranial Magnetic Stimulation
Subjects
Details
- Language :
- English
- ISSN :
- 1558-0776
- Volume :
- 20
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Seminars in pediatric neurology
- Publication Type :
- Academic Journal
- Accession number :
- 23948686
- Full Text :
- https://doi.org/10.1016/j.spen.2013.06.004