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Toward the practical implementation of eye-related bioavailability prediction models.
- Source :
-
Drug discovery today [Drug Discov Today] 2014 Jan; Vol. 19 (1), pp. 31-44. Date of Electronic Publication: 2013 Aug 13. - Publication Year :
- 2014
-
Abstract
- The development and registration of reformulated ophthalmic products (OPs) requires eye-related bioavailability (BA) assessments. Common BA algorithms associated with other routes of application, such as the oral route, cannot be easily applied to eye-related BA testing. Here, we provide an analysis of the current literature and suggestions for further directions in the development of high-capacity, cost-effective, and highly predictive nonclinical models of eye-related drug BA. One, or a combination of these models, has the potential for routine use in research laboratories and/or the pharmaceutical industry to overcome various obstacles in reformulated OP development and registration.<br /> (Copyright © 2013 Elsevier Ltd. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1878-5832
- Volume :
- 19
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Drug discovery today
- Publication Type :
- Academic Journal
- Accession number :
- 23948143
- Full Text :
- https://doi.org/10.1016/j.drudis.2013.08.002