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A study of cortical morphology in children with fetal alcohol spectrum disorders.
- Source :
-
Human brain mapping [Hum Brain Mapp] 2014 May; Vol. 35 (5), pp. 2285-96. Date of Electronic Publication: 2013 Aug 14. - Publication Year :
- 2014
-
Abstract
- Prenatal alcohol exposure is responsible for a broad range of brain structural malformations, which can be studied using magnetic resonance imaging (MRI). Advanced MRI methods have emerged to characterize brain abnormalities, but the teratogenic effects of alcohol on cortical morphology have received little attention to date. Twenty-four 9-year-old children with fetal alcohol spectrum disorders (9 with fetal alcohol syndrome, 15 heavy exposed nonsyndromal children) and 16 age-matched controls were studied to assess the effect of alcohol consumption during pregnancy on cortical morphology. An automated method was applied to 3D T1-weighted images to assess cortical gyrification using global and regional sulcal indices and two region-based morphological measurements, mean sulcal depth and fold opening. Increasing levels of alcohol exposure were related to reduced cortical folding complexity, even among children with normal brain size, indicating a reduction of buried cortical surface. Fold opening was the strongest anatomical correlate of prenatal alcohol intake, indicating a widening of sulci in all regions that were examined. These data identify cortical morphology as a suitable marker for further investigation of brain damage associated with prenatal alcohol exposure.<br /> (Copyright © 2013 Wiley Periodicals, Inc.)
- Subjects :
- Alcohols adverse effects
Analysis of Variance
Case-Control Studies
Cerebral Cortex drug effects
Child
Dose-Response Relationship, Drug
Female
Humans
Image Processing, Computer-Assisted
Magnetic Resonance Imaging
Male
Pregnancy
Prenatal Exposure Delayed Effects physiopathology
South Africa
Brain Mapping
Cerebral Cortex pathology
Fetal Alcohol Spectrum Disorders pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1097-0193
- Volume :
- 35
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Human brain mapping
- Publication Type :
- Academic Journal
- Accession number :
- 23946151
- Full Text :
- https://doi.org/10.1002/hbm.22327