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Texturing formulations for uranium skin decontamination.
- Source :
-
Pharmaceutical development and technology [Pharm Dev Technol] 2014 Sep; Vol. 19 (6), pp. 692-701. Date of Electronic Publication: 2013 Aug 13. - Publication Year :
- 2014
-
Abstract
- Context: Since no specific treatment exists in case of cutaneous contamination by radionuclides such as uranium, a nanoemulsion comprising calixarene molecules, known for their good chelation properties, was previously designed. However, this fluid topical form may be not suitable for optimal application on the skin or wounds.<br />Objective: To develop a texturing pharmaceutical form for the treatment of wounded skins contaminated by uranium.<br />Materials and Methods: The formulations consisted in oil-in-water (O/W) nanoemulsions, loaded with calixarene molecules. The external phase of the initial liquid nanoemulsion was modified with a combination of thermosensitive gelifying polymers: Poloxamer and HydroxyPropylMethylcellulose (HPMC) or methylcellulose (MC). These new formulations were characterized then tested by ex vivo experiments on Franz cells to prevent uranyl ions diffusion through excoriated pig ear skin explants.<br />Results: Despite strong changes in rheological properties, the physico-chemical characteristics of the new nanoemulsions, such as the size and the zeta potential as well as macroscopic aspect were preserved. In addition, on wounded skin, diffusion of uranyl ions, measured by ICP-MS, was limited to less than 5% for both HPMC and MC nanoemulsions.<br />Conclusions: These results demonstrated that a hybrid formulation of nanoemulsion in hydrogel is efficient to treat uranium skin contamination.
- Subjects :
- Administration, Cutaneous
Animals
Calixarenes chemistry
Calixarenes metabolism
Chemistry, Pharmaceutical methods
Decontamination methods
Diffusion
Emulsions chemistry
Emulsions metabolism
Ions metabolism
Particle Size
Polymers chemistry
Polymers pharmacology
Swine
Nanoparticles chemistry
Nanoparticles metabolism
Skin metabolism
Uranium chemistry
Uranium metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1097-9867
- Volume :
- 19
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Pharmaceutical development and technology
- Publication Type :
- Academic Journal
- Accession number :
- 23937529
- Full Text :
- https://doi.org/10.3109/10837450.2013.823991