Back to Search
Start Over
Dopaminergic neuronal imaging in genetic Parkinson's disease: insights into pathogenesis.
- Source :
-
PloS one [PLoS One] 2013 Jul 23; Vol. 8 (7), pp. e69190. Date of Electronic Publication: 2013 Jul 23 (Print Publication: 2013). - Publication Year :
- 2013
-
Abstract
- Objectives: To compare the dopaminergic neuronal imaging features of different subtypes of genetic Parkinson's Disease.<br />Methods: A retrospective study of genetic Parkinson's diseases cases in which DaTSCAN (123I-FP-CIT) had been performed. Specific non-displaceable binding was calculated for bilateral caudate and putamen for each case. The right:left asymmetry index and striatal asymmetry index was calculated.<br />Results: Scans were available from 37 cases of monogenetic Parkinson's disease (7 glucocerebrosidase (GBA) mutations, 8 alpha-synuclein, 3 LRRK2, 7 PINK1, 12 Parkin). The asymmetry of radioligand uptake for Parkinson's disease with GBA or LRRK2 mutations was greater than that for Parkinson's disease with alpha synuclein, PINK1 or Parkin mutations.<br />Conclusions: The asymmetry of radioligand uptake in Parkinsons disease associated with GBA or LRRK2 mutations suggests that interactions with additional genetic or environmental factors may be associated with dopaminergic neuronal loss.
- Subjects :
- Adult
Caudate Nucleus pathology
Cohort Studies
Demography
Dopamine Plasma Membrane Transport Proteins metabolism
Female
Genotype
Humans
Male
Positron-Emission Tomography
Putamen pathology
Tomography, Emission-Computed, Single-Photon
Dopaminergic Neurons pathology
Neuroimaging
Parkinson Disease genetics
Parkinson Disease pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1932-6203
- Volume :
- 8
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- PloS one
- Publication Type :
- Academic Journal
- Accession number :
- 23935950
- Full Text :
- https://doi.org/10.1371/journal.pone.0069190