Back to Search
Start Over
Plasma dihydroceramide species associate with waist circumference in Mexican American families.
- Source :
-
Obesity (Silver Spring, Md.) [Obesity (Silver Spring)] 2014 Mar; Vol. 22 (3), pp. 950-6. Date of Electronic Publication: 2013 Sep 20. - Publication Year :
- 2014
-
Abstract
- Objective: Waist circumference (WC), the clinical marker of central obesity, is gaining popularity as a screening tool for type 2 diabetes (T2D). While there is epidemiologic evidence favoring the WC-T2D association, its biological substantiation is generally weak. Our objective was to determine the independent association of plasma lipid repertoire with WC.<br />Methods: Samples and data from the San Antonio Family Heart Study of 1208 Mexican Americans from 42 extended families were used. Association of plasma lipidomic profiles with the cross-sectionally assessed WC was determined. Plasma lipidomic profiling entailed liquid chromatography with mass spectrometry. Statistical analyses included multivariable polygenic regression models and bivariate trait analyses using the SOLAR software.<br />Results: After adjusting for age and sex interactions, body mass index, homeostasis model of assessment-insulin resistance, total cholesterol, triglycerides, high density lipoproteins and use of lipid lowering drugs, dihydroceramides as a class were associated with WC. Dihydroceramide species 18:0, 20:0, 22:0, and 24:1 were significantly associated and genetically correlated with WC. Two sphingomyelin species (31:1 and 41:1) were also associated with WC.<br />Conclusions: Plasma dihydroceramide levels independently associate with WC. Thus, high resolution plasma lipidomic studies can provide further credence to the biological underpinnings of the association of WC with T2D.<br /> (Copyright © 2013 The Obesity Society.)
- Subjects :
- Adult
Blood Glucose
Cardiovascular Diseases blood
Cardiovascular Diseases ethnology
Cholesterol blood
Cross-Sectional Studies
Diabetes Mellitus, Type 2 blood
Humans
Male
Middle Aged
Multivariate Analysis
Obesity blood
Prevalence
Surveys and Questionnaires
Texas epidemiology
Triglycerides blood
Young Adult
Ceramides blood
Diabetes Mellitus, Type 2 ethnology
Mexican Americans
Obesity ethnology
Waist Circumference
Subjects
Details
- Language :
- English
- ISSN :
- 1930-739X
- Volume :
- 22
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Obesity (Silver Spring, Md.)
- Publication Type :
- Academic Journal
- Accession number :
- 23929697
- Full Text :
- https://doi.org/10.1002/oby.20598