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Identification of immunoreactive proteins of Streptococcus agalactiae isolated from cultured tilapia in China.
- Source :
-
Pathogens and disease [Pathog Dis] 2013 Dec; Vol. 69 (3), pp. 223-31. Date of Electronic Publication: 2013 Sep 19. - Publication Year :
- 2013
-
Abstract
- Streptococcus agalactiae (Group B streptococcus, GBS) is an important zoonotic pathogen that can cause lethal infections in humans and animals, including aquatic species. Immunoreactive proteins of the S. agalactiae strain, GD201008-001, isolated from cultured tilapia in China, were screened by immunoproteomics using hyperimmune sera, convalescent guinea pig sera and GD201008-001-infected tilapia antisera as primary detection antibodies. A total of 16 different proteins were identified including 13 novel immunoreactive proteins of S. agalactiae. Four proteins, serine-rich repeat glycoprotein 1, branched-chain alpha-keto acid dehydrogenase (BKD) subunit E2, 5'-nucleotidase family protein and ornithine carbamoyltransferase, were shown to react with the three types of sera and thus were considered to represent novel S. agalactiae vaccine candidate antigens. Our findings represent the basis for vaccine development for piscine S. agalactiae and are necessary for understanding virulence factors and immunogenicity of S. agalactiae with different hosts.<br /> (© 2013 Federation of European Microbiological Societies. Published by John Wiley & Sons Ltd. All rights reserved.)
- Subjects :
- Animals
Bacterial Proteins immunology
Bacterial Proteins isolation & purification
China
Fish Diseases microbiology
Molecular Sequence Data
Streptococcal Infections veterinary
Streptococcus agalactiae immunology
Bacterial Proteins metabolism
Proteomics methods
Streptococcus agalactiae metabolism
Tilapia microbiology
Subjects
Details
- Language :
- English
- ISSN :
- 2049-632X
- Volume :
- 69
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Pathogens and disease
- Publication Type :
- Academic Journal
- Accession number :
- 23929656
- Full Text :
- https://doi.org/10.1111/2049-632X.12084