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Is green tea a potential trigger for autoimmune hepatitis?

Authors :
Gallo E
Maggini V
Berardi M
Pugi A
Notaro R
Talini G
Vannozzi G
Bagnoli S
Forte P
Mugelli A
Annese V
Firenzuoli F
Vannacci A
Source :
Phytomedicine : international journal of phytotherapy and phytopharmacology [Phytomedicine] 2013 Oct 15; Vol. 20 (13), pp. 1186-9. Date of Electronic Publication: 2013 Aug 06.
Publication Year :
2013

Abstract

A case of autoimmune liver hepatitis is reported: the onset was triggered by consumption of green tea infusion in a patient taking oral contraceptives and irbesartan. We hypothesize that our patient, carrying genetic variant of hepatic metabolism making her particularly susceptible to oxidative stress, developed an abnormal response to a mild toxic insult, afforded by a combination of agents (oral contraceptives+irbesartan+green tea) that normally would not be able to cause damage. Her particular hepatic metabolism further increased the drugs' concentration, favoring the haptenization of liver proteins, eventually leading to the development of an autoimmune hepatitis.<br /> (Copyright © 2013 Elsevier GmbH. All rights reserved.)

Details

Language :
English
ISSN :
1618-095X
Volume :
20
Issue :
13
Database :
MEDLINE
Journal :
Phytomedicine : international journal of phytotherapy and phytopharmacology
Publication Type :
Academic Journal
Accession number :
23928507
Full Text :
https://doi.org/10.1016/j.phymed.2013.07.004