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Is green tea a potential trigger for autoimmune hepatitis?
- Source :
-
Phytomedicine : international journal of phytotherapy and phytopharmacology [Phytomedicine] 2013 Oct 15; Vol. 20 (13), pp. 1186-9. Date of Electronic Publication: 2013 Aug 06. - Publication Year :
- 2013
-
Abstract
- A case of autoimmune liver hepatitis is reported: the onset was triggered by consumption of green tea infusion in a patient taking oral contraceptives and irbesartan. We hypothesize that our patient, carrying genetic variant of hepatic metabolism making her particularly susceptible to oxidative stress, developed an abnormal response to a mild toxic insult, afforded by a combination of agents (oral contraceptives+irbesartan+green tea) that normally would not be able to cause damage. Her particular hepatic metabolism further increased the drugs' concentration, favoring the haptenization of liver proteins, eventually leading to the development of an autoimmune hepatitis.<br /> (Copyright © 2013 Elsevier GmbH. All rights reserved.)
- Subjects :
- Adult
Female
Hepatitis, Autoimmune diagnosis
Hepatitis, Autoimmune drug therapy
Humans
Irbesartan
Liver drug effects
Oxidative Stress
Biphenyl Compounds adverse effects
Contraceptives, Oral adverse effects
Hepatitis, Autoimmune genetics
Polymorphism, Single Nucleotide genetics
Tea adverse effects
Tetrazoles adverse effects
Subjects
Details
- Language :
- English
- ISSN :
- 1618-095X
- Volume :
- 20
- Issue :
- 13
- Database :
- MEDLINE
- Journal :
- Phytomedicine : international journal of phytotherapy and phytopharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 23928507
- Full Text :
- https://doi.org/10.1016/j.phymed.2013.07.004