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Puerperal mastitis: a reproductive event of importance affecting anti-mucin antibody levels and ovarian cancer risk.
- Source :
-
Cancer causes & control : CCC [Cancer Causes Control] 2013 Nov; Vol. 24 (11), pp. 1911-23. Date of Electronic Publication: 2013 Aug 08. - Publication Year :
- 2013
-
Abstract
- Purpose: Test the hypothesis that puerperal mastitis may alter immunity related to the mucin (MUC) family of glycoproteins and lower risk of ovarian cancer.<br />Methods: In two case-control studies conducted in New England between 1998 and 2008, we examined the association between self-reported mastitis and ovarian cancer in 1,483 women with epithelial ovarian cancer and 1,578 controls. IgG1 antibodies against (MUC1) CA15.3 and (MUC16) CA125 were measured using electrochemiluminescence assays in a subset of controls (n = 200). Preoperative CA125 was recorded in 649 cases. The association between ovarian cancer and mastitis was assessed using unconditional logistic regression to calculate adjusted odds ratios, OR, and 95 % confidence intervals (CI). Associations between mastitis and anti-CA15.3 and anti-CA125 antibodies and preoperative CA125 levels were evaluated using adjusted linear regression models.<br />Results: Prior mastitis was associated with a significantly lower risk of ovarian cancer: OR (and 95 % CI) of 0.67 (0.48, 0.94) adjusted for parity, breastfeeding, and other potential confounders. The association was strongest with 2 or more episodes of mastitis, and risk declined progressively with increasing number of children and episodes of mastitis. Among controls, prior mastitis was associated with significantly higher anti-CA15.3 and anti-CA125 antibody levels and, among cases, with significantly lower preoperative CA125 levels.<br />Conclusion: Puerperal mastitis may produce long-lasting anti-mucin antibodies that may lower the risk of ovarian cancer, plausibly through enhanced immune surveillance. Studying immune reactions related to MUC1 and MUC16 in the 10-20 % of breastfeeding women who develop mastitis may suggest ways to duplicate its effects through vaccines based on both antigens.
- Subjects :
- Adult
Antibodies blood
Breast Feeding
CA-125 Antigen immunology
Case-Control Studies
Comorbidity
Electrochemical Techniques methods
Female
Humans
Logistic Models
Luminescent Measurements methods
Mastitis epidemiology
Membrane Proteins immunology
Middle Aged
Mucin-1 immunology
New England epidemiology
Ovarian Neoplasms epidemiology
Parity
Pregnancy
Puerperal Disorders epidemiology
Risk Factors
Young Adult
Antibodies immunology
Mastitis immunology
Mucins immunology
Ovarian Neoplasms immunology
Puerperal Disorders immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1573-7225
- Volume :
- 24
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Cancer causes & control : CCC
- Publication Type :
- Academic Journal
- Accession number :
- 23925696
- Full Text :
- https://doi.org/10.1007/s10552-013-0266-1