Novel role of microRNAs in prostate cancer.

Authors :: Yu JJ
Xia SJ
Source :: Chinese medical journal [Chin Med J (Engl)] 2013; Vol. 126 (15), pp. 2960-4.
Publication Year :: 2013
Abstract: Objective: To discuss the novel biomarkers of microRNAs in prostate cancer.<br />Data Sources: The literatures about microRNAs and prostate cancer cited in this review were obtained mainly from Pubmed published in English from 2004 to 2012.<br />Study Selection: Original articles regarding the novel role of microRNAs in prostate cancer were selected.<br />Results: MicroRNAs play an important role in prostate cancer such as cell differentiation, proliferation, apoptosis, and invasion. Especially microRNAs correlate with prostate cancer cell epithelial-mesenchymal transition (EMT), cancer stem cells (CSCs), drug sensitivity, cancer microenvironment, energy metabolism, androgen independence transformation, and diagnosis prediction.<br />Conclusions: MicroRNAs are involved in various aspects of prostate cancer biology. The role of microRNA in the initiation and development of prostate cancer deserves further study.