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Use of Lipiodol as a drug-delivery system for transcatheter arterial chemoembolization of hepatocellular carcinoma: a review.
- Source :
-
Critical reviews in oncology/hematology [Crit Rev Oncol Hematol] 2013 Dec; Vol. 88 (3), pp. 530-49. Date of Electronic Publication: 2013 Aug 06. - Publication Year :
- 2013
-
Abstract
- Hepatocellular carcinoma (HCC) remains a major public health problem. Transarterial chemoembolization (TACE) is recognized as the standard of care for patients with unresectable, asymptomatic, noninvasive and multinodular HCC. This procedure is based on percutaneous administration of a cytotoxic drug emulsified with Lipiodol followed by embolization of the tumour-feeding arteries. The standard procedure involves Lipiodol, an oily contrast medium which consists of a mixture of long-chain di-iodinated ethyl esters of poppy seed fatty acids. The aim of this review is to discuss the physical properties, tumour uptake behaviour and drug delivery effects of Lipiodol, the parameters influencing tumour uptake and future prospects. Lipiodol has a unique place in TACE as it combines three specific characteristics: drug delivery, transient and plastic embolization and radiopacity properties. Substantial heterogeneity in the physicochemical characteristics of Lipiodol/cytotoxic agent emulsions might reduce the efficacy of this procedure and justifies the current interest in Lipiodol for drug delivery.<br /> (Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.)
- Subjects :
- Animals
Combined Modality Therapy
Ethiodized Oil adverse effects
Ethiodized Oil pharmacokinetics
Humans
Treatment Outcome
Antineoplastic Agents administration & dosage
Carcinoma, Hepatocellular therapy
Chemoembolization, Therapeutic adverse effects
Chemoembolization, Therapeutic methods
Drug Delivery Systems
Ethiodized Oil administration & dosage
Liver Neoplasms therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1879-0461
- Volume :
- 88
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Critical reviews in oncology/hematology
- Publication Type :
- Academic Journal
- Accession number :
- 23921081
- Full Text :
- https://doi.org/10.1016/j.critrevonc.2013.07.003