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Pathological study of otitis media with effusion after treatment with intranasal pulmonary surfactant.
- Source :
-
The Laryngoscope [Laryngoscope] 2013 Dec; Vol. 123 (12), pp. 3148-55. Date of Electronic Publication: 2013 Aug 05. - Publication Year :
- 2013
-
Abstract
- Objectives/hypothesis: To evaluate the histopathological effect of intranasal pulmonary surfactant (PS) on the eustachian tube (ET) in guinea pigs with otitis media with effusion (OME).<br />Study Design: Randomized control trial.<br />Methods: Nonviable heat-killed Hemophilus influenzae solution was injected into the tympanum of guinea pigs by a trans-eardrum approach to establish OME. Guinea pigs were divided into four groups: normal controls (group A), untreated OME (group B), saline-treated (group C), PS-treated (group D). The response threshold of the guinea pigs was measured by auditory brainstem response (ABR), and data were analyzed by one-way analysis of variance. The histopathological changes in the osseous, cartilaginous, and muscular portions of the ET were observed systematically by light microscopy.<br />Results: The ABR threshold in OME group B was raised significantly compared with normal group (A). The response in saline-treated group C was not statistically significantly different compared with OME group B. Seven days after intranasal dripping of pulmonary surfactant in PS-treated group D, the response threshold showed at statistically significant decrease compared with OME B and saline-treated C groups. In OME group B and saline-treated group C, mucosa showed swelling with goblet cell hyperplasia, and cilia were irregularly arranged. In PS-treated group D, there was slight mucosal swelling with fewer goblet cells, and cilia were regularly arranged, similar to the normal group A.<br />Conclusions: The findings of the study indicate that intranasal pulmonary surfactant drops have protective and hyposecretory effects on the mucociliary system of the ET in guinea pigs suffering from OME.<br /> (Copyright © 2013 The American Laryngological, Rhinological and Otological Society, Inc.)
- Subjects :
- Administration, Intranasal
Animals
Disease Models, Animal
Ear, Inner drug effects
Eustachian Tube drug effects
Guinea Pigs
Otitis Media with Effusion chemically induced
Otitis Media with Effusion physiopathology
Otoscopy
Pulmonary Surfactants administration & dosage
Ear, Inner pathology
Eustachian Tube pathology
Evoked Potentials, Auditory, Brain Stem drug effects
Otitis Media with Effusion pathology
Pulmonary Surfactants adverse effects
Subjects
Details
- Language :
- English
- ISSN :
- 1531-4995
- Volume :
- 123
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- The Laryngoscope
- Publication Type :
- Academic Journal
- Accession number :
- 23918455
- Full Text :
- https://doi.org/10.1002/lary.24166