SPARCL1 suppresses metastasis in prostate cancer.

Authors :: Xiang Y
Qiu Q
Jiang M
Jin R
Lehmann BD
Strand DW
Jovanovic B
DeGraff DJ
Zheng Y
Yousif DA
Simmons CQ
Case TC
Yi J
Cates JM
Virostko J
He X
Jin X
Hayward SW
Matusik RJ
George AL Jr
Yi Y
Source :: Molecular oncology [Mol Oncol] 2013 Dec; Vol. 7 (6), pp. 1019-30. Date of Electronic Publication: 2013 Jul 20.
Publication Year :: 2013
Abstract: Purpose: Metastasis, the main cause of death from cancer, remains poorly understood at the molecular level.<br />Experimental Design: Based on a pattern of reduced expression in human prostate cancer tissues and tumor cell lines, a candidate suppressor gene (SPARCL1) was identified. We used in vitro approaches to determine whether overexpression of SPARCL1 affects cell growth, migration, and invasiveness. We then employed xenograft mouse models to analyze the impact of SPARCL1 on prostate cancer cell growth and metastasis in vivo.<br />Results: SPARCL1 expression did not inhibit tumor cell proliferation in vitro. By contrast, SPARCL1 did suppress tumor cell migration and invasiveness in vitro and tumor metastatic growth in vivo, conferring improved survival in xenograft mouse models.<br />Conclusions: We present the first in vivo data suggesting that SPARCL1 suppresses metastasis of prostate cancer.<br /> (Copyright © 2013 Federation of European Biochemical Societies. All rights reserved.)