Back to Search
Start Over
Negative emotional distraction on neural circuits for working memory in patients with posttraumatic stress disorder.
- Source :
-
Brain research [Brain Res] 2013 Sep 19; Vol. 1531, pp. 94-101. Date of Electronic Publication: 2013 Aug 02. - Publication Year :
- 2013
-
Abstract
- Objective: To study the neural mechanism for the impact of negative emotional distraction on working memory in patients with posttraumatic stress disorder (PTSD) resulting from exposure to motor vehicle accidents.<br />Methods: Twenty PTSD patients and 20 healthy subjects were recruited. Event-related functional magnetic resonance imaging (fMRI) was used to investigate the effects of negative and neutral distractors on a delayed-response working memory task. All experiments were performed on a 3.0T MRI scanner, and the functional imaging data were analyzed using SPM8 software.<br />Results: The PTSD group showed poorer performance than the control group when the negative distractors were presented during the delay phase of working memory. The functional imaging indicated that, in the presence of negative relative to neutral distractors, the PTSD group showed higher activation in the emotion processing regions, including amygdala, precuneus and fusiform gyrus, but lower activation in the inferior frontal cortex, insula and left supramarginal gyrus than the control group.<br />Conclusion: Based on the results that activation in the PTSD patients in the presence of negative distractors increased in the emotion-related brain regions but decreased in the working memory-related brain regions, we may conclude that the neural basis of working memory is impaired by negative emotion in PTSD patients.<br /> (© 2013 The Authors. Published by Elsevier B.V. All rights reserved.)
- Subjects :
- Adolescent
Adult
Down-Regulation physiology
Female
Humans
Male
Photic Stimulation methods
Stress Disorders, Post-Traumatic psychology
Young Adult
Attention physiology
Brain physiology
Emotions physiology
Memory, Short-Term physiology
Nerve Net pathology
Nerve Net physiology
Stress Disorders, Post-Traumatic physiopathology
Subjects
Details
- Language :
- English
- ISSN :
- 1872-6240
- Volume :
- 1531
- Database :
- MEDLINE
- Journal :
- Brain research
- Publication Type :
- Academic Journal
- Accession number :
- 23911835
- Full Text :
- https://doi.org/10.1016/j.brainres.2013.07.042