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Phosphorylation and anti-tumor activity of exopolysaccharide from Lachnum YM120.
- Source :
-
Carbohydrate polymers [Carbohydr Polym] 2013 Sep 12; Vol. 97 (2), pp. 690-4. Date of Electronic Publication: 2013 May 23. - Publication Year :
- 2013
-
Abstract
- Phosphorylated polysaccharide PLEP-1a, with the PO₄³⁻ content of 6.39%, was prepared from LEP-1a by phosphorylation. IR, (13)C NMR and (31)P NMR results of PLEP-1a showed that the original basic structure of the polysaccharide was not changed, and the -H₂PO₃ group was linked at C₆ of LEP-1a. The results of anti-tumor experiments in vivo showed that 100 mg/kg and 400 mg/kg of LEP-1a could significantly improve the food consumption, body weight, tumor inhibition rate and thymus index of S180 sarcoma mice, and increase the levels of SOD, IL-2 and TNF-α in mice blood serum, indicating that LEP-1a had an excellent anti-tumor activity. Furthermore, PLEP-1a had a significantly enhanced inhibitory effect on S180 sarcoma mice than LEP-1a, suggesting that phosphorylation is an effective way of improving the biological activity of LEP-1a.<br /> (Copyright © 2013 Elsevier Ltd. All rights reserved.)
- Subjects :
- Animals
Feeding Behavior drug effects
Female
Interleukin-2 metabolism
Magnetic Resonance Spectroscopy
Male
Mice
Organ Specificity drug effects
Phosphates analysis
Phosphorylation drug effects
Reference Standards
Sarcoma 180 enzymology
Sarcoma 180 pathology
Spectrophotometry, Infrared
Superoxide Dismutase metabolism
Tumor Necrosis Factor-alpha metabolism
Weight Gain drug effects
Antineoplastic Agents pharmacology
Ascomycota chemistry
Polysaccharides pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1879-1344
- Volume :
- 97
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Carbohydrate polymers
- Publication Type :
- Academic Journal
- Accession number :
- 23911502
- Full Text :
- https://doi.org/10.1016/j.carbpol.2013.05.033