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Linking HSCs to their youth.

Authors :
Pietras EM
Passegué E
Source :
Nature cell biology [Nat Cell Biol] 2013 Aug; Vol. 15 (8), pp. 885-7.
Publication Year :
2013

Abstract

Fetal haematopoietic stem cells (HSCs) self-renew extensively to build the blood system from scratch. The protein Lin28b negatively regulates the microRNA let-7 to keep levels of its target Hmga2 high, hence conferring high self-renewal potential to fetal HSCs. This regulatory circuit can be experimentally modulated to boost the lower self-renewal activity of quiescent adult HSCs.

Subjects

Subjects :
Animals
RNA-Binding Proteins
DNA-Binding Proteins metabolism
HMGA2 Protein metabolism
Hematopoietic Stem Cells cytology
Hematopoietic Stem Cells metabolism
MicroRNAs metabolism

Details

Language :
English
ISSN :
1476-4679
Volume :
15
Issue :
8
Database :
MEDLINE
Journal :
Nature cell biology
Publication Type :
Periodical
Accession number :
23907190
Full Text :
https://doi.org/10.1038/ncb2817
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