Back to Search
Start Over
Platelets, coagulation and fibrinolysis in breast cancer progression.
- Source :
-
Breast cancer research : BCR [Breast Cancer Res] 2013; Vol. 15 (4), pp. 207. - Publication Year :
- 2013
-
Abstract
- The progression of breast cancer from early-stage to metastatic disease results from a series of events during which malignant cells invade and travel within the bloodstream to distant sites, leading to a clonogenic accumulation of tumor cells in non-breast tissue. While mechanistically complex, an emerging literature supports hemostatic elements as an important patient factor that facilitates the metastatic potential of breast cancer. Hemostatic elements involved include platelets, coagulation, and fibrinolysis. Key steps in breast tumor progression, including cellular transformation, proliferation, tumor cell survival, and angiogenesis, can be mediated by components of the hemostatic system. Thus, the hemostatic system provides potential targets for novel therapeutic approaches to breast cancer therapy with drugs in current use and in development. The present article provides a comprehensive overview of the evidence and mechanisms supporting the roles played by platelets, coagulation activation, and the fibrinolytic system in breast cancer progression.
- Subjects :
- Anticoagulants pharmacology
Anticoagulants therapeutic use
Blood Platelets drug effects
Breast Neoplasms drug therapy
Disease Progression
Female
Fibrinolysis
Hemostasis
Humans
Neovascularization, Pathologic
Platelet Activation
Blood Coagulation drug effects
Blood Platelets physiology
Breast Neoplasms blood
Breast Neoplasms pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1465-542X
- Volume :
- 15
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Breast cancer research : BCR
- Publication Type :
- Academic Journal
- Accession number :
- 23905544
- Full Text :
- https://doi.org/10.1186/bcr3425