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Classical Hodgkin's lymphoma: the Lymphoma Study Association guidelines for relapsed and refractory adult patients eligible for transplant.
- Source :
-
Haematologica [Haematologica] 2013 Aug; Vol. 98 (8), pp. 1185-95. - Publication Year :
- 2013
-
Abstract
- The Hodgkin's Lymphoma Committee of the Lymphoma Study Association (LYSA) gathered in 2012 to prepare guidelines on the management of transplant-eligible patients with relapsing or refractory Hodgkin's lymphoma. The working group is made up of a multidisciplinary panel of experts with a significant background in Hodgkin's lymphoma. Each member of the panel of experts provided an interpretation of the evidence and a systematic approach to obtain consensus was used. Grades of recommendation were not required since levels of evidence are mainly based on phase II trials or standard practice. Data arising from randomized trials are emphasized. The final version was endorsed by the scientific council of the LYSA. The expert panel recommends a risk-adapted strategy (conventional treatment, or single/double transplantation and/or radiotherapy) based on three risk factors at progression (primary refractory disease, remission duration < 1 year, stage III/IV), and an early evaluation of salvage chemosensitivity, including (18)fluorodeoxy glucose-positron emission tomography interpreted according to the Deauville scoring system. Most relapsed or refractory Hodgkin's lymphoma patients chemosensitive to salvage should receive high-dose therapy and autologous stem-cell transplantation as standard. Efforts should be made to increase the proportion of chemosensitive patients by alternating non-cross-resistant chemotherapy lines or exploring the role of novel drugs.
- Subjects :
- Adult
Antineoplastic Combined Chemotherapy Protocols administration & dosage
Hematopoietic Stem Cell Transplantation methods
Hodgkin Disease diagnosis
Humans
Neoplasm Recurrence, Local diagnosis
Randomized Controlled Trials as Topic methods
Randomized Controlled Trials as Topic standards
Salvage Therapy methods
Salvage Therapy standards
Societies, Medical standards
Hematopoietic Stem Cell Transplantation standards
Hodgkin Disease therapy
Neoplasm Recurrence, Local therapy
Practice Guidelines as Topic standards
Subjects
Details
- Language :
- English
- ISSN :
- 1592-8721
- Volume :
- 98
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Haematologica
- Publication Type :
- Academic Journal
- Accession number :
- 23904236
- Full Text :
- https://doi.org/10.3324/haematol.2012.072090