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Increased expression of matrix metalloproteinase-9 associated with gastric ulcer recurrence.
- Source :
-
World journal of gastroenterology [World J Gastroenterol] 2013 Jul 28; Vol. 19 (28), pp. 4590-5. - Publication Year :
- 2013
-
Abstract
- Aim: To compare matrix metalloproteinase (MMP)-9 and tissue inhibitor of metalloproteinase (TIMP)-1 in gastric ulcer (GU) and chronic superficial gastritis (CSG).<br />Methods: This study enrolled 63 patients with GU and 25 patients with CSG. During upper gastroduodenal endoscopy, we took samples of gastric mucosa from the antrum and ulcer site from patients with GU, and samples of antral mucosa from patients with CSG. Mucosal biopsy tissues were cultured for 24 h, and the culture supernatant was measured for levels of MMP-9 and TIMP-1. After receiving eradication therapy for Helicobacter pylori (H. pylori) and 8 wk proton-pump inhibitor therapy for GU, follow-up endoscopy examination was performed after 6 mo and whenever severe symptoms occurred.<br />Results: Levels of MMP-9 and TIMP-1 at the ulcer site or in the antrum were significantly higher in GU than CSG patients. MMP-9 levels at the ulcer site were significantly higher than in the antrum in GU patients, and had a significantly positive correlation with TIMP-1. MMP-9 levels were significantly higher in H. pylori-positive than H. pylori-negative GU and CSG patients. Levels of MMP-9 or TIMP-1 at the ulcer site were associated with the histological severity of activity and inflammation. About 57 GU patients were followed up, and seven had GU recurrence. H. pyloriinfection and MMP-9 levels were risk factors for the recurrence of GU adjusted for age and sex by multiple logistic regression analysis.<br />Conclusion: MMP-9 may perform an important function in gastric ulcer formation and recurrence.
- Subjects :
- Adult
Aged
Anti-Bacterial Agents therapeutic use
Biomarkers metabolism
Biopsy
Chi-Square Distribution
Chronic Disease
Drug Therapy, Combination
Endoscopy, Gastrointestinal
Female
Gastric Mucosa microbiology
Gastric Mucosa pathology
Gastritis enzymology
Helicobacter Infections drug therapy
Helicobacter Infections enzymology
Helicobacter Infections microbiology
Helicobacter pylori isolation & purification
Humans
Logistic Models
Male
Middle Aged
Multivariate Analysis
Odds Ratio
Proton Pump Inhibitors therapeutic use
Recurrence
Risk Factors
Stomach Ulcer drug therapy
Stomach Ulcer microbiology
Stomach Ulcer pathology
Time Factors
Tissue Culture Techniques
Tissue Inhibitor of Metalloproteinase-1 metabolism
Treatment Outcome
Up-Regulation
Young Adult
Gastric Mucosa enzymology
Matrix Metalloproteinase 9 metabolism
Stomach Ulcer enzymology
Subjects
Details
- Language :
- English
- ISSN :
- 2219-2840
- Volume :
- 19
- Issue :
- 28
- Database :
- MEDLINE
- Journal :
- World journal of gastroenterology
- Publication Type :
- Academic Journal
- Accession number :
- 23901237
- Full Text :
- https://doi.org/10.3748/wjg.v19.i28.4590