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Sequential treatment of advanced-stage lung adenocarcinoma harboring wild-type EGFR gene: second-line pemetrexed followed by third-line erlotinib versus the reverse sequence.
- Source :
-
Anticancer research [Anticancer Res] 2013 Aug; Vol. 33 (8), pp. 3397-402. - Publication Year :
- 2013
-
Abstract
- Background: Pemetrexed and erlotinib represent novel agents for the treatment of non-small cell lung cancer (NSCLC). The role of sequential treatment in NSCLC has not been elucidated yet. We compared the efficacy of second-line pemetrexed followed by third-line erlotinib (P-E) to treatment with the reverse sequence (E-P).<br />Patients and Methods: We analyzed data of 57 patients with advanced-stage (IIIB/IV) lung adenocarcinoma harboring wild-type epidermal growth factor receptor (EGFR) gene; 31 patients were treated with P-E and 26 patients with the E-P sequence.<br />Results: The median progression-free survival (PFS) for patients treated with P-E was 3.6 months vs. 7.8 months for patients treated with E-P (p=0.029). The median overall survival (OS) for patients treated with P-E was 7.9 months vs. 26.3 months for patients treated with E-P (p=0.006).<br />Conclusion: The results proved a significant improvement of both PFS and OS for patients treated with the E-P sequence as compared to the P-E sequence.
- Subjects :
- Adenocarcinoma genetics
Adenocarcinoma of Lung
Adult
Aged
Disease-Free Survival
Erlotinib Hydrochloride
Female
Guanine therapeutic use
Humans
Lung Neoplasms genetics
Male
Middle Aged
Neoplasm Staging
Pemetrexed
Adenocarcinoma drug therapy
Adenocarcinoma pathology
Antineoplastic Agents therapeutic use
Antineoplastic Combined Chemotherapy Protocols therapeutic use
ErbB Receptors genetics
Glutamates therapeutic use
Guanine analogs & derivatives
Lung Neoplasms drug therapy
Lung Neoplasms pathology
Quinazolines therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1791-7530
- Volume :
- 33
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Anticancer research
- Publication Type :
- Academic Journal
- Accession number :
- 23898110