First polymer "ruthenium-cyclopentadienyl" complex as potential anticancer agent.

Authors :: Valente A
Garcia MH
Marques F
Miao Y
Rousseau C
Zinck P
Source :: Journal of inorganic biochemistry [J Inorg Biochem] 2013 Oct; Vol. 127, pp. 79-81. Date of Electronic Publication: 2013 Jul 12.
Publication Year :: 2013
Abstract: d-glucose end-capped polylactide ruthenium cyclopentadienyl complex (RuPMC) was newly synthesized by a straightforward method. RuPMC was tested against human MCF7 and MDAMB231 breast and A2780 ovarian adenocarcinoma revealing IC50 values in the micromolar range. A pH dependent hydrolysis is advanced by preliminary UV-visible spectroscopy. Cellular distribution studies showed that RuPMC is predominantly found in the nucleus and in the membrane. Data suggest potential application of RuPMC as a new drug delivery system for Ru(II)Cp compounds.<br /> (© 2013.)

Subjects :: Antineoplastic Agents pharmacology
Cell Survival drug effects
Coordination Complexes pharmacology
Female
Humans
Hydrogen-Ion Concentration
Inhibitory Concentration 50
MCF-7 Cells
Organometallic Compounds pharmacology
Spectrum Analysis
Antineoplastic Agents chemistry
Coordination Complexes chemistry
Organometallic Compounds chemistry
Polymers chemistry
Polymers pharmacology
Ruthenium chemistry

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