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Risk of dementia after anaesthesia and surgery.
- Source :
-
The British journal of psychiatry : the journal of mental science [Br J Psychiatry] 2014 Mar; Vol. 204 (3), pp. 188-93. Date of Electronic Publication: 2013 Jul 25. - Publication Year :
- 2014
-
Abstract
- Background: The potential relationship between anaesthesia, surgery and onset of dementia remains elusive.<br />Aims: To determine whether the risk of dementia increases after surgery with anaesthesia, and to evaluate possible associations among age, mode of anaesthesia, type of surgery and risk of dementia.<br />Method: The study cohort comprised patients aged 50 years and older who were anaesthetised for the first time since 1995 between 1 January 2004 and 31 December 2007, and a control group of randomly selected patients matched for age and gender. Patients were followed until 31 December 2010 to identify the emergence of dementia.<br />Results: Relative to the control group, patients who underwent anaesthesia and surgery exhibited an increased risk of dementia (hazard ratio = 1.99) and a reduced mean interval to dementia diagnosis. The risk of dementia increased in patients who received intravenous or intramuscular anaesthesia, regional anaesthesia and general anaesthesia.<br />Conclusions: The results of our nationwide, population-based study suggest that patients who undergo anaesthesia and surgery may be at increased risk of dementia.
- Subjects :
- Aged
Anesthesia statistics & numerical data
Case-Control Studies
Dementia chemically induced
Female
Humans
Male
Middle Aged
Risk Factors
Surgical Procedures, Operative statistics & numerical data
Taiwan epidemiology
Anesthesia adverse effects
Dementia epidemiology
Surgical Procedures, Operative adverse effects
Subjects
Details
- Language :
- English
- ISSN :
- 1472-1465
- Volume :
- 204
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- The British journal of psychiatry : the journal of mental science
- Publication Type :
- Academic Journal
- Accession number :
- 23887997
- Full Text :
- https://doi.org/10.1192/bjp.bp.112.119610