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Clinical characteristics and neuroimaging findings in 12 cases of recurrent glioblastoma with communicating hydrocephalus.
- Source :
-
Neurologia medico-chirurgica [Neurol Med Chir (Tokyo)] 2013; Vol. 53 (7), pp. 474-81. - Publication Year :
- 2013
-
Abstract
- Clinically, recurrent glioblastoma multiforme (GBM) is often associated with communicating hydrocephalus. We hypothesized that there are specific magnetic resonance (MR) imaging findings at the diagnosis of recurrent GBM that predict subsequent hydrocephalus. Various clinical characteristics were investigated including outcome and MR imaging findings in 12 patients with recurrent GBM followed by hydrocephalus (Hydro group) and 21 patients with recurrent GBM without hydrocephalus (Non-hydro group). Patient age and presence of communicating hydrocephalus were significantly associated with poor outcome. Median survival with recurrent GBM was longer in the Non-hydro group than in the Hydro group. Low Karnofsky performance status (KPS) and poor recursive partitioning analysis (RPA) class (RPA class 3, 5, 6, or 7) at the diagnosis of recurrent GBM were associated with the presence of hydrocephalus. The incidence of leptomeningeal dissemination after recurrent GBM was higher in the Hydro group than in the Non-hydro group. Evans index and fractional anisotropy value showed no difference at the diagnosis of recurrent GBM, but some MR imaging findings indicated that lesion attached to the basal cistern and/or ventricle was closely associated with subsequent hydrocephalus. We recommend careful monitoring of the ventricle size and leptomeningeal dissemination, especially in patients with low KPS and/or poor RPA class, if MR imaging indicates that the lesion is attached to the basal cistern and/or ventricle at recurrence of GBM.
- Subjects :
- Brain Neoplasms mortality
Brain Neoplasms therapy
Cerebral Ventricles pathology
Combined Modality Therapy
Disease Progression
Echo-Planar Imaging
Female
Glioblastoma mortality
Glioblastoma therapy
Humans
Hydrocephalus mortality
Hydrocephalus therapy
Image Enhancement
Image Interpretation, Computer-Assisted
Kaplan-Meier Estimate
Male
Middle Aged
Neoplasm Recurrence, Local mortality
Neoplasm Recurrence, Local therapy
Prognosis
Retrospective Studies
Survival Rate
Brain Neoplasms diagnosis
Glioblastoma diagnosis
Hydrocephalus diagnosis
Magnetic Resonance Imaging
Neoplasm Recurrence, Local diagnosis
Subjects
Details
- Language :
- English
- ISSN :
- 1349-8029
- Volume :
- 53
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Neurologia medico-chirurgica
- Publication Type :
- Academic Journal
- Accession number :
- 23883558
- Full Text :
- https://doi.org/10.2176/nmc.53.474