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Which approach is more effective in the selection of plants with antimicrobial activity?

Authors :
Silva AC
Santana EF
Saraiva AM
Coutinho FN
Castro RH
Pisciottano MN
Amorim EL
Albuquerque UP
Source :
Evidence-based complementary and alternative medicine : eCAM [Evid Based Complement Alternat Med] 2013; Vol. 2013, pp. 308980. Date of Electronic Publication: 2013 Jun 26.
Publication Year :
2013

Abstract

The development of the present study was based on selections using random, direct ethnopharmacological, and indirect ethnopharmacological approaches, aiming to evaluate which method is the best for bioprospecting new antimicrobial plant drugs. A crude extract of 53 species of herbaceous plants collected in the semiarid region of Northeast Brazil was tested against 11 microorganisms. Well-agar diffusion and minimum inhibitory concentration (MIC) techniques were used. Ten extracts from direct, six from random, and three from indirect ethnopharmacological selections exhibited activities that ranged from weak to very active against the organisms tested. The strain most susceptible to the evaluated extracts was Staphylococcus aureus. The MIC analysis revealed the best result for the direct ethnopharmacological approach, considering that some species yielded extracts classified as active or moderately active (MICs between 250 and 1000 µg/mL). Furthermore, one species from this approach inhibited the growth of the three Candida strains. Thus, it was concluded that the direct ethnopharmacological approach is the most effective when selecting species for bioprospecting new plant drugs with antimicrobial activities.

Details

Language :
English
ISSN :
1741-427X
Volume :
2013
Database :
MEDLINE
Journal :
Evidence-based complementary and alternative medicine : eCAM
Publication Type :
Academic Journal
Accession number :
23878595
Full Text :
https://doi.org/10.1155/2013/308980