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Adult pallium transcriptomes surprise in not reflecting predicted homologies across diverse chicken and mouse pallial sectors.
- Source :
-
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2013 Aug 06; Vol. 110 (32), pp. 13150-5. Date of Electronic Publication: 2013 Jul 22. - Publication Year :
- 2013
-
Abstract
- The thorniest problem in comparative neurobiology is the identification of the particular brain region of birds and reptiles that corresponds to the mammalian neocortex [Butler AB, Reiner A, Karten HJ (2011) Ann N Y Acad Sci 1225:14-27; Wang Y, Brzozowska-Prechtl A, Karten HJ (2010) Proc Natl Acad Sci USA 107(28):12676-12681]. We explored which genes are actively transcribed in the regions of controversial ancestry in a representative bird (chicken) and mammal (mouse) at adult stages. We conducted four analyses comparing the expression patterns of their 5,130 most highly expressed one-to-one orthologous genes that considered global patterns of expression specificity, strong gene markers, and coexpression networks. Our study demonstrates transcriptomic divergence, plausible convergence, and, in two exceptional cases, conservation between specialized avian and mammalian telencephalic regions. This large-scale study potentially resolves the complex relationship between developmental homology and functional characteristics on the molecular level and settles long-standing evolutionary debates.
- Subjects :
- Animals
Brain anatomy & histology
Brain metabolism
Chickens
Female
Globus Pallidus anatomy & histology
In Situ Hybridization
Male
Mice
Mice, Inbred C57BL
Models, Anatomic
Models, Genetic
Telencephalon anatomy & histology
Telencephalon metabolism
Time Factors
Gene Expression Profiling methods
Gene Regulatory Networks
Globus Pallidus metabolism
Transcriptome genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1091-6490
- Volume :
- 110
- Issue :
- 32
- Database :
- MEDLINE
- Journal :
- Proceedings of the National Academy of Sciences of the United States of America
- Publication Type :
- Academic Journal
- Accession number :
- 23878249
- Full Text :
- https://doi.org/10.1073/pnas.1307444110